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Idopor(providone iodine complex) is used prevention of microbial infection of skin and mucosa. Potadine has effects on some virus, fungus and most gram positive bacteria. Potadine has three kinds of formulations such as oral gargles, vaginal douches, general antiseptic solution. Our hospital use potadine solutions for gargle for child cancer patients to prevent from infection to oral mucosa in which normal flora have their colonies. We dispense 1% or 2% potadine gargle solution packaged with 300㎖ plastic bottles and used usually 7 days. We studied stability of iodine in solution of plastic bottle, glass bottle, cap opened or closed, concentration (1%, 2%), temperature conditions of room temperature or in refrigerator. The results is as follows. The packaging material, plastic or glass bottle has great effects on povidone iodine solution. The concentration of iodine, 1% diluted, plastic bottle without capping has greatly decreased to below 90% after 7 days laid in refrigerator. But stability of 2% potadine gargle solution in plastic bottle without capping is over 94%. So we should use 2% dilution potadine gargle solution instead of using 1% diluting solution. Packaging material is almostly unaffected for stability of iodine concentration. Stability of iodine gargle solution is not affected by room atmosphere and cool temperature(2-8℃). In vitro bactericidal activities are really excellent. Normal oral florae is disinfected almost completely in condition of contacting time over 30 seconds with potadine gargle solution.
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